The aim of this investigation was to determine the effect of the application of vegetative herbicides on the weed infestation and the productivity in cultivars common winter wheat. The investigations were carried out during 2018–2021 at Dobrudzha Agricultural Institute – General Toshevo (DAI). The following herbicides were used: Ergon WG (50 g/ha), Starane Gold (1800 ml/ha), Biatlon 4D+Desh (50g/ha+500ml/ha) and Korelo Duo+Das Oil (260.5 g/ha+500ml/ha) from the group of sulfunylureas with various mechanism of action. The preparations were applied at stage 29 and 37 (according to Zadoks) of three cultivars common winter wheat, Rada, Kosara and Pchelina. The herbicide effect was determined by the quantitative weight method and evaluated by the EWRS scale. Four-factor dispersion analysis was applied. The factors year conditions, cultivar, herbicide and stage were followed. Regardless of the cultivars and the stage of treatment, Starane gold  had highest efficiency (100%) against the following investigated weeds: Sinapis arvensis L., Matricaria chamomilla L., Anthemis arvensis L., Galium tricorne (Stock.), Consolida orientalis (J. Gay) and Cirsium arvensis L. Ergon WG, Biatlon 4D+Desh and Korelo Duo+Das Oil had 100% efficiency against Sinapis arvensis L., Matricaria chamomilla L., Anthemis arvensis L. and Cirsium arvensis L. and lower effect (90-94%) on Galium tricorne (Stock), Consolida orientalis (J. Gay). The factors with highest strength of effect were the year conditions (60%) and the used cultivar (30%).