The percentage of seed germination and growth of young plants of wheat crops (Triticum vulgare L.), barley (Hordeum vulgare L.) and maize (Zea mays L.) on the substrate of the mine dump of Kišnica mine and its surrounding area was studied. The growth of young plants was monitored for 25 days from sowing. The results obtained during the study showed that the percentage of seed germination and the growth of the studied plants varied depending on both the plant species and on the concentration of the pollutants in the used soil from different sites, as well as the distance of the sites from the pollutant emitters. The highest percentage of germination was observed in wheat seeds from the site Gračanica (3 km away from the emitter) and the smallest percentage of germination was found in barley seeds from the site Kišnica mine. The fastest growth was recorded in the wheat from the site Gračanica, and the greatest inhibition during plant growth was recorded in the corn from the site Kišnica mine pit where the height of stem was only 2.45% compared to the control. Toxic substances (heavy metals from the mine dump of Kišnica mine) had the inhibitory effect on the seed germination. Low concentrations of heavy metals in the soil from Gračanica stimulated the growth of plants that, after 25 days of growth, was stopped in all the plants growing on that soil. However, high concentrations of heavy metals inhibited seed germination and the growth of young plants on the substrate from Kišnica mine. The inhibition or stimulation of seed germination and the growth of young plants in the presence of heavy metals in the soil was caused by the inhibition or activation of the enzymatic system responsible for the metabolic processes during morphogenesis.